A meteor radar chain located along the 120°E meridian in the Northern Hemisphere from low to middle latitudes provides long-term horizontal wind observations of the mesosphere and lower thermosphere (MLT) region. In this study, we report a seasonal variation and its latitudinal feature in the horizontal mean wind in the MLT region observed by six meteor radar instruments located at Mohe (53.5°N, 122.3°E), Beijing (40.3°N, 116.2°E), Mengcheng (33.4°N, 116.5°E), Wuhan (30.6°N, 114.4°E), Kunming (25.6°N, 108.3°E), and Fuke (19.5°N, 109.1°E) stations. In addition, we compare the wind in the MLT region measured by the meteor radar stations with those simulated by the Whole Atmosphere Community Climate Model (WACCM). In general, the WACCM appears to capture well the seasonal and latitudinal variations in the zonal wind component. In particular, the temporal evolution of the eastward zonal wind maximum shifts from July to May as the latitude decreases. However, the simulated WACCM meridional wind exhibits differences from the meteor radar observations.